Reds Opening Day Parade 2025 Location. Businesses throughout downtown are getting ready for opening day. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati.

18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. The opening day parade is scheduled for march 27th.